Studies on Tubercle Bacillus-histiocyte Relationship

Studies of Tubercle Bacillus-histiocyte Relationships* Vii. Homologous and Heterologous Transi~er of Cellular Resistance

A form of cellular resistance which has been intensively investigated in our laboratories is one that is directed against Mycobacterium tuberculosis. This cellular resistance, which is readily demonstrated with the histiocytes of rabbits immunized with the BCG strain of tubercle bacillus, is expressed in a number of ways depending upon the conditions of experimentation; one expression of this r...

STUDIES ON TUBERCLE BACILLUS-MONOCYTE RELATIONSHIP* II. INDUCTION O~ MONOCYTE DEGENERATION BY BACTERIA AND CULTu_V,E F~TRATE: SPECIFICITY 0]~ SERUM AND MONOCYTE EIIECTS ON P~ESISTANCE TO DEGENERATION

Studies of acquired immunity have revolved around the relative importance of humoral and cellular factors. As previously indicated (1), valid conclusions concerning the role of cells in acquired immunity against tuberculosis require analyses of bacterium-cell relationships during periods when the in dtro cell populations show no change in cell numbers. Under such conditions, it was observed tha...

Further Studies on the Survival Time of the Bovine Tubercle Bacillus in Soil, Soil and Dung, in Dung and on Grass, with Experiments on Feeding Guinea-pigs and Calves on Grass Artificially Infected with Bovine Tubercle Bacilli.

Studies on Tubercle Bacillus-monocyte Relationship

Studies of the conditions necessary for maintenance of constant cell populations in vitro in the Mackaness type of culture chamber have indicated the importance of preliminary trypsinization of cells and the beneficial effect of 40 per cent rabbit serum in Tyrode's solution. Under these optimal conditions, uninfected suspensions of monocytes exhibited little change in cell numbers over a period...

Retina and the tubercle Bacillus: Four decades of our journey and current understanding

Tuberculosis continues to be a major pandemic with enormous public health implication. Involvement of ocular tissues in the form of tubercles, tuberculomas, panophthalmitis, and iris granulomas are well recognized as definitive manifestations of tuberculosis. For these lesions, confirmatory evidence is available in the form of demonstration of acid-fast Bacillus on Ziehl-Neelsen staining. For o...